Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.40 |
| ▸ | LGMN | Q99538 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783171 | 0.92 | PRKDC (0.49) | PRKDCMAPTPKMALDH1A1PIK3CD | |
| SCHEMBL5440744 | 0.91 | MAPT (0.52) | PRKDCMAPTPKMALDH1A1PIK3CD | |
| SCHEMBL5441394 | 0.85 | PRKDC (0.50) | PRKDCMAPTPKMPIK3CDPIK3CA | |
| SCHEMBL14802143 | 0.83 | PRKDC (0.52) | PRKDCMAPTPKMPIK3CDPIK3CA | |
| SCHEMBL5440694 | 0.82 | PRKDC (0.55) | PRKDCMAPTALDH1A1KDM4EMGAM | |
| SCHEMBL5782473 | 0.82 | PRKDC (0.49) | PRKDCMAPTPKMALDH1A1KDM4E | |
| SCHEMBL5781920 | 0.82 | PRKDC (0.53) | PRKDCMAPTPKMPIK3CDPIK3CA | |
| SCHEMBL5453418 | 0.81 | PRKDC (0.52) | PRKDCMAPTPKMPIK3CDPIK3CA | |
| SCHEMBL5444190 | 0.80 | PRKDC (0.56) | PRKDCMAPTMGAMGAAUSP8 | |
| SCHEMBL14802144 | 0.79 | ALDH1A1 (0.47) | PRKDCMAPTALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404681-B2 | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | LUITPOLD PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |