Sugi Predict

Sugi Predict / Compounds / SCHEMBL5453418

SCHEMBL5453418

SCHEMBL5453418

O=c1c2ccc(F)cc2oc2cc(N3CCOCC3)cc(O)c12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKDC P78527 6/20 0.52
▸ CCR4 P51679 1/20 0.45
▸ MGAM O43451 3/20 0.43
▸ GAA P10253 2/20 0.43
▸ SI P14410 2/20 0.43
▸ MGAM2 Q2M2H8 2/20 0.43
▸ MAOA P21397 2/20 0.42
▸ FASN P49327 2/20 0.42
▸ MMP1 P03956 1/20 0.42
▸ PTPN1 P18031 1/20 0.42
▸ MAPT P10636 1/20 0.41
▸ PKM P14618 1/20 0.41
▸ POLB P06746 1/20 0.40
▸ PIK3CD O00329 2/20 0.40
▸ PIK3CB P42338 2/20 0.40
▸ PIK3CA P42336 1/20 0.40
▸ PIK3CG P48736 1/20 0.40
▸ ABCB1 P08183 1/20 0.39
▸ ATP1A1 P05023 1/20 0.39
▸ ATP1B1 P05026 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5440694 0.88 PRKDC (0.55) PRKDCMGAMGAASIMGAM2
SCHEMBL5781920 0.87 PRKDC (0.53) PRKDCMGAMGAASIMGAM2
SCHEMBL14802143 0.86 PRKDC (0.52) PRKDCCCR4MGAMGAASI
SCHEMBL5454434 0.84 MGAM (0.63) PRKDCMGAMGAASIMGAM2
SCHEMBL5441394 0.84 PRKDC (0.50) PRKDCCCR4MGAMGAASI
SCHEMBL5444190 0.83 PRKDC (0.56) PRKDCMGAMGAAMAOAMAPT
SCHEMBL5456126 0.82 PRKDC (0.48) PRKDCMGAMGAASIMGAM2
SCHEMBL14447676 0.82 PRKDC (0.37) PRKDCCCR4MAOAMAPTPIK3CD
SCHEMBL14802145 0.81 PRKDC (0.47) PRKDCMGAMGAASIMGAM2
SCHEMBL5783171 0.81 PRKDC (0.49) PRKDCMGAMGAASIMGAM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404681-B2 Xanthones, thioxanthones and acridinones as DNA-PK inhibitors LUITPOLD PHARMACEUTICALS, INC. (US) 2013-03-26 — — US disclosed
US-8404681-B2 Xanthones, thioxanthones and acridinones as DNA-PK inhibitors LUITPOLD PHARMACEUTICALS, INC. (US) 2013-03-26 — — US disclosed
US-8404681-B2 Xanthones, thioxanthones and acridinones as DNA-PK inhibitors LUITPOLD PHARMACEUTICALS, INC. (US) 2013-03-26 — — US disclosed
US-20070167441-A1 Xanthones, thioxanthones and acridinones as dna-pk inhibitors LUITPOLD PHARMACEUTICALS, INC. 2007-07-19 — — US disclosed
US-20070167441-A1 Xanthones, thioxanthones and acridinones as dna-pk inhibitors LUITPOLD PHARMACEUTICALS, INC. 2007-07-19 — — US disclosed
US-20070167441-A1 Xanthones, thioxanthones and acridinones as dna-pk inhibitors LUITPOLD PHARMACEUTICALS, INC. 2007-07-19 — — US disclosed
EP-1660473-A2 XANTHONES, THIOXANTHONES AND ACRIDINONES AS DNA-PK INHIBITORS Luitpold Pharmaceuticals, Inc. (US) 2006-05-31 — — EP disclosed
WO-2004085418-A2 XANTHONES, THIOXANTHONES AND ACRIDINONES AS DNA-PK INHIBITORS LUITPOLD PHARMACEUTICALS, INC. (US) 2004-10-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070167441-A1 Xanthones, thioxanthones and acridinones as dna-pk inhibitors DCK, DTYMK, XPA PRKDC 12/4885CCR4 3692/4885MGAM 3500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.