Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299228 | 0.85 | CA12 (0.43) | UTS2RPDE2APANK3TP53MAPT | |
| SCHEMBL27634082 | 0.84 | UTS2R (0.40) | UTS2RPDE2APANK3TP53MAPT | |
| SCHEMBL2765266 | 0.79 | CNR2 (0.39) | PANK3TP53MAPTALDH1A1 | |
| SCHEMBL84043 | 0.74 | PDE2A (0.53) | PDE2AAKR1C3AKR1C2PTPN5KIF11 | |
| Ammonia Solution, Strong SCHEMBL27642816 | 0.72 | PDE2A (0.52) | PDE2AAKR1C3AKR1C2PTPN5KIF11 | |
| SCHEMBL2859953 | 0.70 | UTS2R (0.37) | UTS2RPDE2APANK3TP53MAPT | |
| SCHEMBL855311 | 0.70 | FFAR1 (0.55) | MAPTALDH1A1 | |
| SCHEMBL27290792 | 0.70 | FPR2 (0.47) | TP53MAPTEEF2KALDH1A1 | |
| SCHEMBL29331540 | 0.69 | PDE2A (0.46) | PDE2AAKR1C3AKR1C2 | |
| Ethylamine SCHEMBL27563059 | 0.69 | PDE2A (0.50) | PDE2APTPN5KIF11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656141-A1 | TREATMENT FOR ALZHEIMER S DISEASE AND RELATED CONDITIONS | MERCK SHARP & DOHME LTD. (GB) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005013985-A1 | TREATMENT FOR ALZHEIMER'S DISEASE AND RELATED CONDITIONS | MERCK SHARP & DOHME LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |