Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018603 | 0.88 | NNMT (0.47) | PARP1NNMTTDP1SIRT3KMT2A | |
| SCHEMBL29889389 | 0.88 | NNMT (0.47) | PARP1NNMTTDP1SIRT3KMT2A | |
| SCHEMBL10661542 | 0.84 | PARP1 (0.41) | PARP1IKBKBNNMTTDP1SIRT3 | |
| SCHEMBL6232283 | 0.84 | CYP3A4 (0.40) | TDP1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL93998 | 0.82 | KDM4E (0.50) | TDP1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL30340194 | 0.82 | KDM4E (0.50) | TDP1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL4807602 | 0.82 | CYP3A4 (0.39) | IKBKBTDP1KMT2AALDH1A1MAPT | |
| SCHEMBL28215256 | 0.81 | PARP1 (0.42) | PARP1IKBKBNNMTTDP1SIRT3 | |
| SCHEMBL529786 | 0.80 | TSHR (0.54) | PARP1ALDH1A1MAPTTSHRBRD4 | |
| SCHEMBL28695987 | 0.80 | CYP3A4 (0.37) | TDP1KMT2AALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108084096-A | 2- phenyl pyrimidine classes compound, preparation method and medical usage | 中国药科大学 | 2018-05-29 | — | — | CN | disclosed |
| CN-104744636-B | Isoprene-vinyl aromatic hydrocarbon copolymer and method for producing same | 奇美实业股份有限公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-104744636-A | Isoprene-vinyl aromatic hydrocarbon copolymer and method for producing same | CHIMEI CORP | 2015-07-01 | — | — | CN | disclosed |
| CN-102558442-B | Modified conjugated diene-vinyl aromatic hydrocarbon copolymer and method for producing same | CHI MEI CORP | 2015-03-18 | — | — | CN | disclosed |
| CN-103328561-B | Electrically conductive rubber elastomer, charging member, and electrophotographic apparatus | CANON KK | 2014-12-10 | — | — | CN | disclosed |
| CN-104024228-A | Imidazolidinedione compounds and their uses | HINOVA PHARMACEUTICALS INC | 2014-09-03 | — | — | CN | disclosed |
| CN-103328561-A | Electrically conductive rubber elastomer, charging member, and electrophotographic apparatus | CANON KK | 2013-09-25 | — | — | CN | disclosed |
| CN-103159680-A | Imidazole diketone compound and application thereof | AMYNIDY PHARMACEUTICAL CO LTD | 2013-06-19 | — | — | CN | disclosed |
| CN-102558442-A | Modified conjugated diene-vinyl aromatic hydrocarbon copolymer and method for producing same | CHI MEI CORP | 2012-07-11 | — | — | CN | disclosed |
| EP-1212318-B1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2006-01-25 | — | — | EP | disclosed |
| US-20050009898-A1 | New substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-01-13 | — | — | US | disclosed |
| US-6794395-B1 | Substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-09-21 | — | — | US | disclosed |
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| CN-1083863-C | Water-unsolutable azo-pigment based on N-acetoacetyl dehydrogenated thio toluidine | CLARIANT GMBH (DE) | 2002-05-01 | — | — | CN | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |
| CN-1169446-A | Water-unsolutable azo-pigment based on N-acetoacetyl dehydrogenated thio toluidine | HOECHST AG (DE) | 1998-01-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009898-A1 | New substituted indolinones, their manufacture and their use as medicaments | CCNE1, CDK1, CCNI | PARP1 1403/4885IKBKB 770/4885NNMT 2148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.