Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.56 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.56 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.56 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 5/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | EEF2K | O00418 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202179 | 0.90 | ATM (0.58) | SLC1A3SLC1A2SLC1A1KCNA5F2 | |
| SCHEMBL2204265 | 0.85 | KCNA5 (0.52) | SLC1A3SLC1A2SLC1A1KCNA5F2 | |
| SCHEMBL6496422 | 0.83 | SLC1A3 (0.61) | SLC1A3SLC1A2SLC1A1F2PRSS1 | |
| SCHEMBL27580332 | 0.83 | SLC1A3 (0.61) | SLC1A3SLC1A2SLC1A1F2PRSS1 | |
| SCHEMBL27410492 | 0.80 | SLC1A3 (0.53) | SLC1A3SLC1A2SLC1A1F2PRSS1 | |
| SCHEMBL5674838 | 0.78 | ATM (0.49) | ATML3MBTL1EEF2KALDH1A1CYP1A2 | |
| SCHEMBL13985124 | 0.77 | SLC1A3 (0.56) | SLC1A3SLC1A2SLC1A1F2PRSS1 | |
| SCHEMBL6652039 | 0.77 | SLC1A3 (0.56) | SLC1A3SLC1A2SLC1A1F2PRSS1 | |
| SCHEMBL2693257 | 0.77 | SLC1A3 (0.63) | SLC1A3SLC1A2SLC1A1KCNA5F2 | |
| SCHEMBL7785619 | 0.76 | ATM (0.42) | SLC1A3SLC1A2SLC1A1KCNA5F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631542-A1 | BICYCLIC COMPOUNDS HAVING BRADYKININ RECEPTORS AFFINITY AND PHARMACEUTICAL COMPOSITIONS THEREOF | Amgen, Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004092116-A1 | BICYCLIC COMPOUNDS HAVING BRADYKININ RECEPTORS AFFINITY AND PHARMACEUTICAL COMPOSITIONS THEREOF | AMGEN, INC. (US) | 2004-10-28 | — | — | WO | disclosed |