Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | EEF2K | O00418 | 4/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.55 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.55 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.47 |
| ▸ | ITGAV | P06756 | 3/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783709 | 0.90 | SLC1A3 (0.56) | ATML3MBTL1EEF2KSLC1A3SLC1A2 | |
| SCHEMBL2204265 | 0.87 | KCNA5 (0.52) | ATML3MBTL1EEF2KSLC1A3SLC1A2 | |
| SCHEMBL8684370 | 0.82 | SLC1A3 (0.60) | SLC1A3SLC1A2SLC1A1CASP1TSHR | |
| SCHEMBL6945237 | 0.81 | KCNA5 (0.57) | ATML3MBTL1EEF2KALDH1A1KCNA5 | |
| SCHEMBL9154395 | 0.80 | SLC1A3 (0.54) | SLC1A3SLC1A2SLC1A1CASP1ALDH1A1 | |
| SCHEMBL5683299 | 0.80 | CASP1 (0.82) | SLC1A3SLC1A2SLC1A1CASP1ALDH1A1 | |
| SCHEMBL7785619 | 0.80 | ATM (0.42) | ATML3MBTL1EEF2KSLC1A3SLC1A2 | |
| SCHEMBL2693257 | 0.79 | SLC1A3 (0.63) | SLC1A3SLC1A2SLC1A1CASP1ALDH1A1 | |
| SCHEMBL7785621 | 0.78 | ITGB3 (0.48) | ATML3MBTL1EEF2KSLC1A3SLC1A2 | |
| SCHEMBL28404274 | 0.78 | ATM (0.76) | ATML3MBTL1EEF2KALDH1A1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278319-B2 | Substituted spiroamine compounds | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | disclosed |
| EP-2344457-A1 | SUBSTITUTED SPIROAMINES | Grünenthal GmbH (DE) | 2011-07-20 | — | — | EP | disclosed |
| US-20100113417-A1 | Substituted Spiroamine Compounds | GRUENENTHAL GMBH (DE) | 2010-05-06 | — | — | US | disclosed |
| WO-2010049146-A1 | SUBSTITUTED SPIROAMINES | Grünenthal GmbH (DE) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113417-A1 | Substituted Spiroamine Compounds | BDKRB1, BDKRB2, REN | ATM 1737/4885L3MBTL1 3336/4885EEF2K 4273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.