Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | PRKDC | P78527 | 10/20 | 0.46 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | CDC14B | O60729 | 1/20 | 0.40 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | BRD2 | P25440 | 2/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16182148 | 0.85 | ALOX5 (0.57) | ALOX5PRKDCGGPS1PIK3CDPIK3CB | |
| SCHEMBL16182153 | 0.85 | ALOX5 (0.57) | ALOX5PRKDCGGPS1PIK3CDPIK3CB | |
| SCHEMBL16182136 | 0.85 | ALOX5 (0.57) | ALOX5PRKDCGGPS1PIK3CDPIK3CB | |
| SCHEMBL26750759 | 0.83 | ALOX5 (0.59) | ALOX5PRKDCGGPS1PIK3CDPIK3CB | |
| SCHEMBL23313986 | 0.83 | ALOX5 (0.54) | ALOX5PRKDCGGPS1PTGES2SMN1; SMN2 | |
| SCHEMBL21588510 | 0.83 | ALOX5 (0.57) | ALOX5PRKDCGGPS1PIK3CDPIK3CB | |
| SCHEMBL21431853 | 0.81 | ALOX5 (0.59) | ALOX5PRKDCGGPS1PIK3CDPIK3CB | |
| SCHEMBL11712766 | 0.81 | ALOX5 (0.63) | ALOX5PRKDCGGPS1PIK3CDPIK3CB | |
| SCHEMBL23438797 | 0.81 | ALOX5 (0.51) | ALOX5PRKDCGGPS1PIK3CDPIK3CB | |
| SCHEMBL15195381 | 0.79 | ALOX5 (0.51) | ALOX5PRKDCGGPS1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622886-A2 | SUBSTITUTED AMINO CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004099171-A2 | SUBSTITUTED AMINO CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | disclosed |