Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | TDO2 | P48775 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GABRP | O00591 | 1/20 | 0.55 |
| ▸ | GABRD | O14764 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2721049 | 0.84 | KDM4E (0.68) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL1060136 | 0.81 | TDO2 (0.63) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL11490695 | 0.81 | KDM4E (0.71) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL27905044 | 0.81 | KDM4E (0.75) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL9204360 | 0.80 | KDM4E (0.65) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL27917573 | 0.78 | KDM4E (0.59) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL5053765 | 0.77 | KDM4E (0.58) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL10642447 | 0.77 | KDM4E (0.58) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL11159950 | 0.76 | KDM4E (0.60) | KDM4ETDO2MAPTMEN1MAPK1 | |
| SCHEMBL10020899 | 0.75 | TDO2 (0.64) | KDM4ETDO2MAPTMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1332144-B1 | INDOLE DERIVATIVES AS PDE5-INHIBITORS | LILLY ICOS LLC (US) | 2006-08-23 | — | — | EP | disclosed |
| US-6878711-B2 | Indole derivatives as PDE5-inhibitors | LILLY ICOS LLC (US) | 2005-04-12 | — | — | US | disclosed |
| US-20030229080-A1 | Indole derivatives as pde5-inhibitors | LILLY ICOS LLC A DELAWARE CORPORATION | 2003-12-11 | — | — | US | disclosed |
| EP-1332144-A1 | INDOLE DERIVATIVES AS PDE5-INHIBITORS | Lilly Icos LLC (US) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002036593-A1 | INDOLE DERIVATIVES AS PDE5-INHIBITORS | LILLY ICOS LLC (US) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229080-A1 | Indole derivatives as pde5-inhibitors | PDE5A, PDE3A, PDE2A | KDM4E 1239/4885TDO2 143/4885MAPT 1519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.