Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785999 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL8992515 | 0.76 | HRH4 (0.36) | LMNAMIFTSHRHRH2HRH1 | |
| SCHEMBL4720914 | 0.75 | HRH4 (0.35) | LMNAMIFTSHRHRH2HRH1 | |
| SCHEMBL28295612 | 0.75 | NOS3 (0.41) | HRH4HRH3 | |
| SCHEMBL3019488 | 0.75 | HRH1 (0.56) | HRH1 | |
| SCHEMBL22783595 | 0.75 | HRH4 (0.38) | LMNAMIFTSHRHRH2HRH1 | |
| SCHEMBL28861085 | 0.75 | HRH3 (0.38) | ALDH1A1MAPK1LMNAMIFTSHR | |
| Bromide SCHEMBL28670044 | 0.73 | HRH3 (0.37) | ALDH1A1MAPK1LMNAMIFTSHR | |
| SCHEMBL11448189 | 0.72 | HRH2 (0.35) | LMNAMIFTSHRHRH2HRH1 | |
| Bromide SCHEMBL29291042 | 0.71 | HTR2A (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689391-A2 | 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | Novartis AG (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005021519-A2 | 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | NOVARTIS AG (CH) | 2005-03-10 | — | — | WO | disclosed |