Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 0.84 |
| ▸ | ATM | Q13315 | 2/20 | 0.84 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.84 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.84 |
| ▸ | NPY1R | P25929 | 1/20 | 0.84 |
| ▸ | NPY2R | P49146 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | HPGD | P15428 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.72 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628193 | 0.93 | TDP1 (0.86) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL12789168 | 0.91 | MAPT (1.00) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL12790096 | 0.90 | TDP1 (0.82) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL30620397 | 0.90 | TDP1 (0.82) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL12790014 | 0.87 | IRAK4 (0.77) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL14108023 | 0.85 | TDP1 (0.73) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL30081396 | 0.85 | TDP1 (0.74) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL3054920 | 0.85 | MAPT (0.72) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL31610089 | 0.83 | MAPT (0.69) | TDP1MAPTATMNPSR1L3MBTL1 | |
| SCHEMBL11511135 | 0.83 | HDAC1 (0.74) | TDP1MAPTATMNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3430010-B1 | 5-ETHYL-4-METHYL-PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING ACTIVITY AS AGONIST OF TAAR | HOFFMANN LA ROCHE (CH) | 2020-07-15 | — | — | EP | disclosed |
| WO-2017157873-A1 | 5-ETHYL-4-METHYL-PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING ACTIVITY AS AGONIST OF TAAR | F. HOFFMANN-LA ROCHE AG (CH) | 2017-09-21 | — | — | WO | disclosed |
| US-20110092475-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-04-21 | — | — | US | disclosed |
| EP-1723132-A1 | EP2 RECEPTOR AGONISTS | ASTERAND UK LIMITED (GB) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005080367-A1 | EP2 RECEPTOR AGONISTS | PHARMAGENE LABORATORIES LIMITED (GB) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092475-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | SULT1E1, SULT2A1, SULT1A1 | TDP1 3913/4885MAPT 918/4885ATM 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.