SCHEMBL578638

SCHEMBL578638

C=CC1CCC(NC(=O)OC(C)(C)C)CC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BTK Q06187 1/20 0.49
KDM1A O60341 1/20 0.46
MAOB P27338 1/20 0.46
CTSK P43235 2/20 0.46
GAA P10253 2/20 0.44
EPHX1 P07099 1/20 0.43
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
DRD2 P14416 4/20 0.41
KCNA3 P22001 1/20 0.40
EPHX2 P34913 1/20 0.40
NFKB1 P19838 1/20 0.40
NFKB2 Q00653 1/20 0.40
RELA Q04206 1/20 0.40
CYP2C9 P11712 1/20 0.39
HSD11B1 P28845 1/20 0.39
KMT2A Q03164 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL578639 1.00 BTK (0.49) BTKKDM1AMAOBCTSKGAA
SCHEMBL3702152 0.86 BTK (0.61) BTKKDM1AMAOBCTSKGAA
SCHEMBL1406894 0.86 BTK (0.61) BTKKDM1AMAOBCTSKGAA
SCHEMBL10343938 0.86 BTK (0.61) BTKKDM1AMAOBCTSKGAA
SCHEMBL3702157 0.86 BTK (0.61) BTKKDM1AMAOBCTSKGAA
SCHEMBL2963241 0.85 BTK (0.50) BTKKDM1AMAOBCTSKGAA
SCHEMBL19560741 0.85 BTK (0.50) BTKKDM1AMAOBCTSKGAA
SCHEMBL1607763 0.85 BTK (0.50) BTKKDM1AMAOBCTSKGAA
SCHEMBL1422443 0.85 BTK (0.50) BTKKDM1AMAOBCTSKGAA
SCHEMBL15584722 0.85 BTK (0.50) BTKKDM1AMAOBCTSKGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023142754-A1 EZH1/2 INHIBITOR, PREPARATION THEREOF, AND USE THEREOF IN ANTI-TUMOR THERAPY 江苏天士力帝益药业有限公司 2023-08-03 WO disclosed
CN-111479814-A Fused pyridines as H-PGDS inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2020-07-31 CN disclosed
WO-2016024096-A1 ANTIBACTERIAL COMPOUNDS REDX PHARMA PLC (GB) 2016-02-18 WO disclosed
EP-2297107-B1 [4-(1-AMINO-ETHYL) -CYCLOHEXYL]-METHYL-AMINE AND [6-(1-AMINO-ETHYL) -TETRAHYDRO- PYRAN-3-YL]-METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS ACTELION PHARMACEUTICALS LTD (CH) 2013-11-13 EP disclosed
EP-2417141-B1 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY ACTELION PHARMACEUTICALS LTD (CH) 2013-10-16 EP disclosed
US-8415375-B2 2-hydroxyethyl-1H-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity ACTELION PHARMACEUTICALS LTD. (CH) 2013-04-09 US disclosed
US-8349829-B2 [4-(1-amino-ethyl)-cyclohexyl]-methyl-amine and [6-(1-amino-ethyl)-tetrahydro-pyran-3-yl]-methyl-amine derivatives as antibacterials ACTELION PHARMACEUTICALS LTD. (CH) 2013-01-08 US disclosed
US-20120040989-A1 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY ACTELION PHARMACEUTICALS LTD. (CH) 2012-02-16 US disclosed
EP-2417141-A1 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY Actelion Pharmaceuticals Ltd. (CH) 2012-02-15 EP disclosed
US-20110288084-A1 [4-( 1-AMINO-ETHYL) - CYCLOHEXYL ] - METHYL - AMINES AS ANTIBACTERIALS ASTRAZENECA AB (SE) 2011-11-24 US disclosed
EP-2370444-A1 [4- (1-AMINO-ETHYL) -CYCLOHEXYL]-METHYL-AMINES AS ANTIBACTERIALS AstraZeneca AB (SE) 2011-10-05 EP disclosed
US-20110082132-A1 [4-(1-AMINO-EHTYL) - CYCLOHEXYL] -METHYL-AMINE AND [6-(1-AMINO-EHTYL) -TETRAHYDRO-PYRAN-3-YL] -METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS ACTELION PHARMACEUTICALS LTD. (CH) 2011-04-07 US disclosed
EP-2297107-A1 Ý4-(1-AMINO-ETHYL) -CYCLOHEXYL¨-METHYL-AMINE AND Ý6-(1-AMINO-ETHYL) -TETRAHYDRO- PYRAN-3-YL¨-METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS Actelion Pharmaceuticals Ltd. (CH) 2011-03-23 EP disclosed
WO-2010116337-A1 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY ACTELION PHARMACEUTICALS LTD (CH) 2010-10-14 WO disclosed
WO-2010055348-A1 [4- (1-AMINO-ETHYL) -CYCLOHEXYL] -METHYL-AMINES AS ANTIBACTERIALS ASTRAZENECA AB (SE) 2010-05-20 WO disclosed
WO-2009147616-A1 [4-(1-AMINO-ETHYL) -CYCLOHEXYL] -METHYL-AMINE AND [6-(1-AMINO-ETHYL) -TETRAHYDRO- PYRAN-3-YL] -METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS ACTELION PHARMACEUTICALS LTD (CH) 2009-12-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120040989-A1 2-HYDROXYETHYL-1H-QUINOLIN-2-ONE DERIVATIVES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY NQO2, AZI2, Q6ZSR9 BTK 2821/4885KDM1A 84/4885MAOB 1653/4885
US-20110082132-A1 [4-(1-AMINO-EHTYL) - CYCLOHEXYL] -METHYL-AMINE AND [6-(1-AMINO-EHTYL) -TETRAHYDRO-PYRAN-3-YL] -METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS DOT1L, EHMT1, Q6ZSR9 BTK 2385/4885KDM1A 90/4885MAOB 399/4885
US-20110288084-A1 [4-( 1-AMINO-ETHYL) - CYCLOHEXYL ] - METHYL - AMINES AS ANTIBACTERIALS AAAS, EEF1A1, ACMSD BTK 2104/4885KDM1A 321/4885MAOB 52/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.