Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845413 | 1.00 | POLB (0.48) | POLBKDM4EMEN1TP53MAPK1 | |
| SCHEMBL5783456 | 0.85 | CCR3 (0.46) | CCR3 | |
| SCHEMBL5783883 | 0.79 | POLB (0.58) | POLBKDM4EMEN1TP53MAPK1 | |
| SCHEMBL5743129 | 0.78 | HRH2 (0.49) | KDM4EMEN1KMT2AFAAHALDH1A1 | |
| SCHEMBL5743133 | 0.78 | HRH2 (0.49) | KDM4EMEN1KMT2AFAAHALDH1A1 | |
| SCHEMBL5030322 | 0.78 | KDM1A (0.57) | POLBKDM4EMEN1KMT2AFAAH | |
| SCHEMBL5061297 | 0.75 | POLB (0.51) | POLBMAPK1ATML3MBTL1ALDH1A1 | |
| SCHEMBL4039589 | 0.74 | MCHR1 (0.56) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5787119 | 0.73 | FAAH (0.46) | POLBKDM4EMEN1TP53MAPK1 | |
| SCHEMBL4037010 | 0.73 | CXCR3 (0.50) | KDM4EMEN1KMT2AATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680408-A2 | CCR3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040129-A2 | CCR3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |