Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 5/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | PTPN22 | Q9Y2R2 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787297 | 0.89 | ADAMTS4 (0.44) | ADAMTS4MMP2RORCPTPN22MAPT | |
| SCHEMBL3896601 | 0.89 | ADAMTS4 (0.62) | ADAMTS4MMP2RORCPTPN22MAPT | |
| SCHEMBL5789992 | 0.85 | ADAMTS4 (0.50) | ADAMTS4MMP2MAPTMMP14MMP13 | |
| SCHEMBL13314510 | 0.78 | ADAMTS4 (0.80) | ADAMTS4MMP2MMP14MMP13MMP7 | |
| SCHEMBL3608574 | 0.78 | ADAMTS4 (0.80) | ADAMTS4MMP2MMP14MMP13MMP7 | |
| SCHEMBL14042765 | 0.78 | ADAMTS4 (0.49) | ADAMTS4MMP2MAPTMMP14MMP13 | |
| SCHEMBL3904143 | 0.78 | ADAMTS4 (0.55) | ADAMTS4MMP2PTPN22MAPTMMP14 | |
| SCHEMBL3907917 | 0.73 | ADAMTS4 (0.62) | ADAMTS4MMP2RORCMMP14MMP13 | |
| SCHEMBL3609279 | 0.73 | ADAMTS4 (0.63) | ADAMTS4MMP2MMP14MMP13MMP7 | |
| SCHEMBL7402456 | 0.68 | TAS2R14 (0.67) | MMP2RORCMMP14MMP13RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692124-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | Wyeth (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005061477-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH (US) | 2005-07-07 | — | — | WO | claimed |