Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3934914 | 0.99 | POLB (0.54) | POLBTSHRHSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL3922436 | 0.94 | POLB (0.53) | POLBTSHRHSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL5786359 | 0.90 | SMN1; SMN2 (0.50) | POLBTSHRHSD17B10SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL3919147 | 0.89 | SMN1; SMN2 (0.49) | POLBTSHRHSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL5785794 | 0.86 | POLB (0.46) | POLBTSHRHSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL3932353 | 0.86 | POLB (0.45) | POLBTSHRHSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL3924415 | 0.84 | POLB (0.49) | POLBTSHRHSD17B10SMN1; SMN2KMT2A | |
| SCHEMBL3922481 | 0.84 | TP53 (0.47) | POLBTSHRSMN1; SMN2KMT2AHPGD | |
| SCHEMBL5785462 | 0.83 | TSPO (0.50) | POLBTSHRHSD17B10SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL3923392 | 0.83 | TSPO (0.49) | POLBTSHRHSD17B10SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458721-B1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2006-11-22 | — | — | EP | disclosed |