Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | UGCG | Q16739 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758984 | 0.90 | KDM4E (0.45) | ELANEKDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6215080 | 0.84 | RECQL (0.44) | ELANEKDM4EALDH1A1SMN1; SMN2LSS | |
| SCHEMBL5755996 | 0.84 | CCR1 (0.48) | ELANEKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5759223 | 0.83 | RECQL (0.48) | ELANEKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5758300 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5755639 | 0.72 | CYP1A2 (0.48) | KDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5755268 | 0.70 | ALDH1A1 (0.48) | KDM4EALDH1A1HTT | |
| SCHEMBL5757140 | 0.70 | HPGD (0.54) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27644620 | 0.68 | TP53 (0.41) | KDM4EALDH1A1HTT | |
| SCHEMBL5757397 | 0.66 | ELANE (0.75) | ELANEKDM4EALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | disclosed |