Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755268 | 0.90 | ALDH1A1 (0.48) | ALDH1A1KDM4EHTTHCRTR1HCRTR2 | |
| SCHEMBL5755639 | 0.88 | CYP1A2 (0.48) | ALDH1A1KDM4EHTTSMN1; SMN2HPGD | |
| SCHEMBL5758984 | 0.88 | KDM4E (0.45) | ALDH1A1KDM4EHTTHCRTR1HCRTR2 | |
| SCHEMBL5757140 | 0.86 | HPGD (0.54) | ALDH1A1KDM4ESMN1; SMN2HPGDTP53 | |
| SCHEMBL6215080 | 0.82 | RECQL (0.44) | ALDH1A1KDM4ESMN1; SMN2HPGDTP53 | |
| SCHEMBL27644620 | 0.79 | TP53 (0.41) | ALDH1A1KDM4EHTTHCRTR1HCRTR2 | |
| SCHEMBL5755694 | 0.78 | HPGD (0.44) | ALDH1A1KDM4EHTTSMN1; SMN2HPGD | |
| SCHEMBL5789313 | 0.78 | ELANE (0.41) | ALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL5757751 | 0.76 | HPGD (0.52) | ALDH1A1KDM4EHPGDTP53MAPT | |
| SCHEMBL5755996 | 0.75 | CCR1 (0.48) | ALDH1A1KDM4EHTTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | disclosed |
| US-20060035938-A1 | 2-Pyridone derivatives as inhibitors of neutrophile elastase | ASRAZENECA AB (SE) | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035938-A1 | 2-Pyridone derivatives as inhibitors of neutrophile elastase | SERPINB1, ELANE, SERPINE1 | ALDH1A1 1465/4885KDM4E 3110/4885HTT 4034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.