Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788434 | 0.88 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5790470 | 0.87 | SLC6A2 (0.46) | CHEK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5791315 | 0.80 | ADRA2C (0.51) | SLC6A2SLC6A4SLC6A3HRH1 | |
| SCHEMBL13708225 | 0.73 | SLC6A2 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3HRH1 | |
| SCHEMBL13708224 | 0.73 | SLC6A2 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3HRH1 | |
| SCHEMBL4073636 | 0.73 | SLC6A2 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3HRH1 | |
| SCHEMBL5791765 | 0.73 | SLC6A2 (0.62) | KCNH2SLC6A2SLC6A4SLC6A3HRH1 | |
| SCHEMBL5048095 | 0.72 | SLC6A2 (0.80) | CHEK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL3328234 | 0.70 | HTR2A (0.53) | CHEK1KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8556225 | 0.70 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716126-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005066144-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |