Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788434 | 0.91 | SLC6A2 (0.49) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL5789337 | 0.87 | CHEK1 (0.43) | SLC6A2SLC6A3SLC6A4CHEK1 | |
| SCHEMBL5791315 | 0.80 | ADRA2C (0.51) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL5791765 | 0.78 | SLC6A2 (0.62) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL7497207 | 0.76 | DRD4 (0.51) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL8924483 | 0.72 | DRD4 (0.51) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL78044 | 0.72 | DRD4 (0.51) | SLC6A2SLC6A3SLC6A4ADRB2HTR1A | |
| SCHEMBL13708222 | 0.71 | SLC6A2 (0.48) | SLC6A2SLC6A3SLC6A4ADRB2 | |
| SCHEMBL13708220 | 0.71 | SLC6A2 (0.48) | SLC6A2SLC6A3SLC6A4ADRB2 | |
| SCHEMBL4082354 | 0.71 | SLC6A2 (0.48) | SLC6A2SLC6A3SLC6A4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716126-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005066144-A1 | MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |