Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | TNF | P01375 | 3/20 | 0.38 |
| ▸ | LITAF | Q99732 | 3/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1140469 | 0.69 | MAPK14 (0.61) | HTTNPSR1 | |
| SCHEMBL4882095 | 0.69 | BTK (0.48) | BTKMAPTKDM4ENPSR1 | |
| SCHEMBL5788459 | 0.69 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL29782315 | 0.68 | BTK (1.00) | BTK | |
| SCHEMBL17699567 | 0.68 | BTK (1.00) | BTK | |
| SCHEMBL3149529 | 0.68 | PKMYT1 (0.33) | — | |
| SCHEMBL4889085 | 0.67 | MAPK14 (0.51) | BTKTRPA1MAPTLMNANPSR1 | |
| SCHEMBL23231088 | 0.64 | HTR1A (0.48) | TNFLITAFTRPA1KDM4EGLA | |
| SCHEMBL31104438 | 0.64 | HTR1A (0.48) | TNFLITAFTRPA1KDM4EGLA | |
| SCHEMBL30523106 | 0.64 | ABCB1 (0.49) | MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682520-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042502-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-12 | — | — | WO | disclosed |