Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GYS1 | P13807 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 9/20 | 0.43 |
| ▸ | RAB9A | P51151 | 9/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1756442 | 0.75 | POLB (0.73) | GYS1POLBNPC1RAB9AKMT2A | |
| SCHEMBL3554717 | 0.74 | GYS1 (0.52) | GYS1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL13059119 | 0.72 | GYS1 (1.00) | GYS1POLBNPC1RAB9AKMT2A | |
| SCHEMBL3561659 | 0.72 | GYS1 (1.00) | GYS1POLBNPC1RAB9AKMT2A | |
| SCHEMBL3564920 | 0.72 | GYS1 (1.00) | GYS1POLBNPC1RAB9AKMT2A | |
| SCHEMBL3560136 | 0.71 | GYS1 (0.94) | GYS1POLBNPC1RAB9AKMT2A | |
| SCHEMBL3563799 | 0.70 | KMT2A (0.79) | POLBNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3554718 | 0.70 | GYS1 (0.50) | GYS1POLBNPC1RAB9AKMT2A | |
| SCHEMBL3562170 | 0.69 | ALDH1A1 (0.53) | GYS1POLBNPC1RAB9AKMT2A | |
| SCHEMBL3565441 | 0.69 | GYS1 (0.75) | GYS1POLBNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663936-A1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005000781-A1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-06 | — | — | WO | disclosed |