Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442961 | 0.79 | HDAC1 (0.51) | HDAC3HDAC1HDAC2PPARGPPARA | |
| SCHEMBL12706067 | 0.73 | RAB9A (0.65) | NPC1RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL29493490 | 0.70 | IRAK4 (0.66) | IRAK4MEN1KMT2AHTT | |
| SCHEMBL29639528 | 0.70 | IRAK4 (0.66) | IRAK4MEN1KMT2AHTT | |
| SCHEMBL29639517 | 0.70 | IRAK4 (0.66) | IRAK4MEN1KMT2AHTT | |
| SCHEMBL27676562 | 0.70 | HDAC3 (0.53) | NPC1RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL5790108 | 0.70 | HDAC6 (0.57) | HDAC3HDAC1HDAC2PPARGMEN1 | |
| SCHEMBL7477122 | 0.70 | NPC1 (0.56) | NPC1RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL21446851 | 0.69 | PRSS1 (0.58) | NPC1RAB9APLAUMEN1KMT2A | |
| SCHEMBL18322706 | 0.69 | IRAK4 (0.55) | NPC1RAB9AIRAK4PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611088-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | claimed |
| WO-2004092115-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS INC. (US) | 2004-10-28 | — | — | WO | claimed |