Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 8/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5790686 | 0.87 | IDO1 (0.51) | IDO1MAOBSLC1A1NR4A2FFAR1 | |
| SCHEMBL5792856 | 0.86 | SLC1A3 (0.44) | IDO1AGXTSLC1A1KDM4EMAPK1 | |
| SCHEMBL5790274 | 0.86 | IDO1 (0.45) | IDO1CHRM3MAOBFFAR1KDM4E | |
| SCHEMBL5790287 | 0.85 | SLC6A4 (0.44) | IDO1AGXTCHRM3SLC1A1 | |
| SCHEMBL5793923 | 0.85 | IDO1 (0.44) | IDO1AGXTCHRM3MAOBHCAR2 | |
| SCHEMBL5790213 | 0.85 | PKM (0.48) | IDO1AGXTMAOBHCAR2FFAR1 | |
| SCHEMBL5790390 | 0.84 | TACR1 (0.50) | IDO1 | |
| SCHEMBL5791244 | 0.84 | IDO1 (0.48) | IDO1AGXTCHRM3MAOBFFAR1 | |
| SCHEMBL5792475 | 0.83 | CETP (0.43) | — | |
| SCHEMBL5790666 | 0.81 | TACR1 (0.47) | IDO1SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006014942-A1 | ARYLOXYALKYLAMINE NK-1/SSRI INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-09 | — | — | WO | disclosed |