Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | RBP4 | P02753 | 7/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5968438 | 0.91 | GAA (0.44) | GAATDP1HTR2CRBP4PNMT | |
| SCHEMBL16269184 | 0.77 | HTR2C (0.41) | GAATDP1HTR2CRBP4PNMT | |
| SCHEMBL15670008 | 0.73 | HTR2C (0.49) | GAATDP1HTR2CRBP4PNMT | |
| SCHEMBL17987098 | 0.72 | CHRNB2 (0.53) | GAATDP1HTR2CRBP4 | |
| SCHEMBL14945579 | 0.71 | RBP4 (0.61) | GAAHTR2CRBP4DRD3GRM2 | |
| SCHEMBL16964887 | 0.71 | HTR2C (0.48) | GAATDP1HTR2CRBP4PNMT | |
| SCHEMBL16964888 | 0.71 | HTR2C (0.48) | GAATDP1HTR2CRBP4PNMT | |
| SCHEMBL16109566 | 0.71 | HTR2C (0.48) | GAATDP1HTR2CRBP4PNMT | |
| SCHEMBL29511855 | 0.71 | HTR2C (0.48) | GAATDP1HTR2CRBP4PNMT | |
| SCHEMBL14908034 | 0.71 | HTR2C (0.48) | GAATDP1HTR2CRBP4PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000811-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |