Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | GPR4 | P46093 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500170 | 0.90 | CTSK (0.58) | CTSKCTSLCTSSCTSBGPR4 | |
| SCHEMBL8270732 | 0.90 | CTSK (0.47) | CTSKCTSLCTSSCTSBJAK2 | |
| SCHEMBL8270035 | 0.89 | CTSK (0.51) | CTSKCTSLCTSSCTSBGPR4 | |
| SCHEMBL14004314 | 0.88 | ABL1 (0.41) | CTSKCTSLCTSSCTSBCHRM3 | |
| Trifluoroacetic Acid SCHEMBL3317688 | 0.86 | CTSK (0.54) | CTSKCTSLCTSSCTSBGPR4 | |
| Trifluoroacetic Acid SCHEMBL5794393 | 0.85 | CTSK (0.44) | CTSKCTSLCTSSCTSBACVR1 | |
| SCHEMBL8270467 | 0.84 | CTSK (0.48) | CTSKCTSLCTSSCTSBGPR4 | |
| SCHEMBL5793222 | 0.81 | CTSK (0.41) | CTSKCTSLCTSSCTSBGPR4 | |
| SCHEMBL5791503 | 0.80 | CTSK (0.47) | CTSKCTSLCTSSCTSBGPR4 | |
| SCHEMBL8270522 | 0.80 | CTSK (0.51) | CTSKCTSLCTSSCTSBGPR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2008112156-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |