Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 4/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | GPR4 | P46093 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270779 | 0.90 | CTSK (0.40) | CTSKIDO1CTSLFGFR4ALDH1A1 | |
| SCHEMBL5790636 | 0.89 | CTSK (0.44) | CTSKCTSLFGFR4CTSBCTSS | |
| SCHEMBL8271448 | 0.88 | CTSK (0.46) | CTSKCTSLFGFR4HTTHDAC1 | |
| SCHEMBL8270467 | 0.88 | CTSK (0.48) | CTSKCTSLFGFR4HPGDCTSB | |
| SCHEMBL8268844 | 0.88 | CTSK (0.45) | CTSKCTSLFGFR4ALDH1A1CTSB | |
| SCHEMBL8271447 | 0.87 | CTSK (0.43) | CTSKFGFR4HDAC3HDAC1HDAC2 | |
| SCHEMBL8270485 | 0.86 | CTSK (0.37) | CTSKIDO1CTSLFGFR4ALDH1A1 | |
| SCHEMBL5791384 | 0.85 | CTSK (0.45) | CTSKFGFR4CTSSHTT | |
| SCHEMBL8270696 | 0.85 | CTSL (0.47) | CTSKIDO1CTSLFGFR4ALDH1A1 | |
| SCHEMBL5793878 | 0.84 | CTSK (0.37) | CTSKIDO1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |