Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270745 | 0.94 | CTSL (0.59) | CTSLCTSBCTSSCTSKJAK2 | |
| Trifluoroacetic Acid SCHEMBL5793410 | 0.92 | CTSK (0.65) | CTSLCTSBCTSSCTSKHDAC6 | |
| Trifluoroacetic Acid SCHEMBL5791240 | 0.90 | CTSK (0.57) | CTSLCTSBCTSSCTSKJAK2 | |
| Trifluoroacetic Acid SCHEMBL5794393 | 0.90 | CTSK (0.44) | CTSLCTSBCTSSCTSKJAK2 | |
| Trifluoroacetic Acid SCHEMBL5793415 | 0.88 | CTSL (0.43) | CTSLCTSBCTSSCTSKHDAC4 | |
| SCHEMBL8270031 | 0.85 | CTSK (0.72) | CTSLCTSBCTSSCTSKJAK2 | |
| SCHEMBL8270732 | 0.85 | CTSK (0.47) | CTSLCTSBCTSSCTSKJAK2 | |
| SCHEMBL8270525 | 0.84 | CTSK (0.63) | CTSLCTSBCTSSCTSKJAK2 | |
| Trifluoroacetic Acid SCHEMBL5794344 | 0.83 | CTSL (0.43) | CTSLCTSBCTSSCTSKALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5592743 | 0.83 | CTSL (0.62) | CTSLCTSBCTSSCTSKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |