Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MPO | P05164 | 12/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | SPR | P35270 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791310 | 0.94 | MPO (0.61) | TSHRMPONOTUMMTNR1AMTNR1B | |
| SCHEMBL28364289 | 0.83 | MPO (0.69) | TSHRMPONOTUMMTNR1AMTNR1B | |
| SCHEMBL9293385 | 0.82 | MEN1 (0.68) | TSHRKMT2A | |
| SCHEMBL4463076 | 0.80 | MPO (0.67) | TSHRMPONOTUMMTNR1AMTNR1B | |
| SCHEMBL29902243 | 0.80 | MPO (0.76) | TSHRMPONOTUMMTNR1AMTNR1B | |
| SCHEMBL3655654 | 0.80 | MPO (0.76) | TSHRMPONOTUMMTNR1AMTNR1B | |
| SCHEMBL351449 | 0.78 | MPO (0.69) | TSHRMPONOTUMMTNR1AMTNR1B | |
| SCHEMBL5203631 | 0.78 | MPO (0.80) | TSHRMPONOTUMMTNR1AMTNR1B | |
| SCHEMBL2260803 | 0.77 | TSHR (1.00) | TSHRMPONOTUMMTNR1AMTNR1B | |
| SCHEMBL20242784 | 0.76 | NOTUM (0.78) | TSHRMPONOTUMMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651637-A1 | 3-AMINO CHROMAN AND 2-AMINO TETRALIN DERIVATIVES | Wyeth (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005012291-A1 | 3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES | WYETH (US) | 2005-02-10 | — | — | WO | disclosed |