Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.48 |
| ▸ | CTSL | P07711 | 6/20 | 0.46 |
| ▸ | CTSS | P25774 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270735 | 0.91 | CTSK (0.43) | CTSKCTSLCTSSJAK2JAK3 | |
| SCHEMBL5500170 | 0.88 | CTSK (0.58) | CTSKCTSLCTSSCTSB | |
| Trifluoroacetic Acid SCHEMBL5793233 | 0.87 | CTSK (0.40) | CTSKCTSLCTSSJAK2JAK3 | |
| Trifluoroacetic Acid SCHEMBL3317688 | 0.83 | CTSK (0.54) | CTSKCTSLCTSSCTSB | |
| SCHEMBL8243959 | 0.83 | CTSK (0.51) | CTSKCTSLCTSSJAK2JAK3 | |
| SCHEMBL5791503 | 0.83 | CTSK (0.47) | CTSKCTSLCTSSCTSBHDAC3 | |
| SCHEMBL8270732 | 0.81 | CTSK (0.47) | CTSKCTSLCTSSJAK2JAK3 | |
| SCHEMBL8268844 | 0.81 | CTSK (0.45) | CTSKCTSLCTSSCTSBMEN1 | |
| SCHEMBL8270467 | 0.81 | CTSK (0.48) | CTSKCTSLCTSSCTSB | |
| SCHEMBL8270035 | 0.81 | CTSK (0.51) | CTSKCTSLCTSSJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2008112156-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |