Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791890 | 0.81 | XIAP (0.43) | HDAC4SMN1; SMN2 | |
| SCHEMBL4838300 | 0.80 | HDAC4 (0.40) | HDAC4SMN1; SMN2EPHX2 | |
| SCHEMBL5793469 | 0.79 | KDM1A (0.44) | KDM1AOPRK1KCNH2HTRA1SCN3A | |
| SCHEMBL5794434 | 0.79 | KDM1A (0.44) | KDM1AOPRK1KCNH2HTRA1SCN3A | |
| SCHEMBL5792160 | 0.79 | KDM1A (0.46) | KDM1ASMN1; SMN2OPRK1 | |
| SCHEMBL5821182 | 0.79 | KDM1A (0.46) | KDM1ASMN1; SMN2OPRK1 | |
| SCHEMBL5793810 | 0.77 | KDM1A (0.47) | KDM1AHDAC4SMN1; SMN2OPRK1EPHX2 | |
| SCHEMBL5793048 | 0.77 | KDM1A (0.47) | KDM1AHDAC4SMN1; SMN2OPRK1EPHX2 | |
| SCHEMBL5794455 | 0.75 | KDM1A (0.48) | KDM1AHDAC4HRH3KCNH2LIPE | |
| SCHEMBL8314605 | 0.74 | KDM1A (0.42) | KDM1AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |