Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794434 | 1.00 | KDM1A (0.44) | KDM1AHSD17B2KIF11HTRA1KCNH2 | |
| SCHEMBL5794437 | 0.83 | XIAP (0.43) | KIF11KCNH2 | |
| SCHEMBL5793470 | 0.83 | XIAP (0.43) | KIF11KCNH2 | |
| SCHEMBL5793580 | 0.79 | KDM1A (0.41) | KDM1AKCNH2MEN1KMT2ASCN3A | |
| SCHEMBL5791886 | 0.79 | KDM1A (0.47) | KDM1AHTRA1KCNH2OPRK1SCN3A | |
| SCHEMBL5794093 | 0.77 | KDM1A (0.45) | KDM1AHTRA1MEN1KMT2ASCN3A | |
| SCHEMBL5794664 | 0.77 | KDM1A (0.45) | KDM1AHTRA1MEN1KMT2ASCN3A | |
| SCHEMBL4834200 | 0.73 | PSEN1 (0.49) | HSD17B2 | |
| SCHEMBL4843496 | 0.73 | PSEN1 (0.49) | HSD17B2 | |
| SCHEMBL4841673 | 0.73 | PSEN1 (0.49) | HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |