Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268834 | 0.94 | MAPK8 (0.39) | CTSKMAPK8MAPK9ANO1P2RX7 | |
| Trifluoroacetic Acid SCHEMBL5791900 | 0.89 | CTSK (0.44) | CTSKMAPK8MAPK9CTSSCTSL | |
| Trifluoroacetic Acid SCHEMBL5792623 | 0.89 | HPGD (0.39) | CTSKMAPK8MAPK9NPC1MEN1 | |
| Trifluoroacetic Acid SCHEMBL5790897 | 0.85 | CTSK (0.38) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL8270504 | 0.83 | MAPK8 (0.40) | CTSKMAPK8MAPK9ANO1CTSS | |
| SCHEMBL8271456 | 0.83 | CTSK (0.47) | CTSKMAPK8MAPK9CTSSCTSL | |
| Trifluoroacetic Acid SCHEMBL5794677 | 0.83 | CTSK (0.39) | CTSKANO1CTSSCTSLCTSB | |
| Trifluoroacetic Acid SCHEMBL5792604 | 0.82 | CTSK (0.43) | CTSKCTSSCTSLCTSBMEN1 | |
| Trifluoroacetic Acid SCHEMBL5792007 | 0.82 | MAPT (0.37) | CTSKMAPK8MAPK9CTSSCTSL | |
| SCHEMBL8268835 | 0.82 | HPGD (0.43) | MAPK8MAPK9NPC1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |