Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | CD38 | P28907 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1767524 | 0.83 | TDP1 (0.46) | CD38MEN1KMT2AMAPTKDM4E | |
| SCHEMBL28213057 | 0.78 | TSHR (0.42) | PARP1AURKARPS6KB1MEN1KMT2A | |
| SCHEMBL15926013 | 0.76 | CYP1A2 (0.43) | ARCYP2D6HRH1MEN1KMT2A | |
| SCHEMBL15389131 | 0.75 | NPC1 (0.43) | PARP1ARCYP2D6MEN1KMT2A | |
| SCHEMBL29818128 | 0.75 | PARP10 (0.48) | PARP1AURKARPS6KB1HRH1KDM4E | |
| SCHEMBL166483 | 0.75 | PARP10 (0.48) | PARP1AURKARPS6KB1HRH1KDM4E | |
| SCHEMBL31038176 | 0.75 | JAK2 (0.44) | AURKARPS6KB1 | |
| SCHEMBL28778421 | 0.75 | JAK2 (0.44) | AURKARPS6KB1 | |
| SCHEMBL7134588 | 0.75 | TSHR (0.54) | PARP1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL13562419 | 0.73 | CYP1A2 (0.46) | CYP2D6HRH1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592070-A2 | Tetrazole-substituted arylamides | F. Hoffmann-La Roche AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2006011719-A1 | N-SUBSTITUTED-SULFAMOYLBENZOIC ACID DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | B & C BIOPHARM CO., LTD. (KR) | 2006-02-02 | — | — | WO | disclosed |