Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28778421 | 1.00 | JAK2 (0.44) | JAK2MBOAT4AURKARPS6KB1LRRK2 | |
| SCHEMBL933463 | 0.79 | CA1 (0.55) | AURKARPS6KB1CA1CA2CA9 | |
| SCHEMBL5791960 | 0.75 | PARP1 (0.38) | AURKARPS6KB1 | |
| SCHEMBL29563944 | 0.74 | MBOAT4 (0.44) | JAK2MBOAT4 | |
| SCHEMBL29818128 | 0.74 | PARP10 (0.48) | AURKARPS6KB1L3MBTL1 | |
| SCHEMBL166483 | 0.74 | PARP10 (0.48) | AURKARPS6KB1L3MBTL1 | |
| SCHEMBL2697225 | 0.72 | KMT2A (0.47) | JAK2AURKALRRK2SYK | |
| SCHEMBL29488691 | 0.72 | KMT2A (0.47) | JAK2AURKALRRK2SYK | |
| SCHEMBL1853274 | 0.72 | LMNA (0.42) | JAK2MBOAT4 | |
| SCHEMBL28536047 | 0.72 | MBOAT4 (0.43) | JAK2MBOAT4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114436955-B | Tetrahydroquinoline and benzomorpholine derivatives or salts thereof, and preparation method and application thereof | 复旦大学 | 2024-08-09 | — | — | CN | disclosed |