Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845496 | 1.00 | MEN1 (0.36) | MEN1KMT2ASMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL4839870 | 0.81 | ALDH1A1 (0.44) | MEN1KMT2ASMN1; SMN2TSHRTDP1 | |
| SCHEMBL4843507 | 0.81 | ALDH1A1 (0.44) | MEN1KMT2ASMN1; SMN2TSHRTDP1 | |
| SCHEMBL5791105 | 0.81 | ALDH1A1 (0.44) | MEN1KMT2ASMN1; SMN2TSHRTDP1 | |
| SCHEMBL8314206 | 0.80 | NPSR1 (0.34) | MEN1KMT2ASMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL4833337 | 0.80 | NPSR1 (0.34) | MEN1KMT2ASMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL4834022 | 0.80 | GRM2 (0.33) | TP53MDM2GRM2LMNA | |
| SCHEMBL4834368 | 0.80 | GRM2 (0.33) | TP53MDM2GRM2LMNA | |
| SCHEMBL4841082 | 0.80 | ALDH1A1 (0.38) | MEN1KMT2ASMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL4841551 | 0.80 | ALDH1A1 (0.38) | MEN1KMT2ASMN1; SMN2TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |