Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701189 | 0.83 | MEN1 (0.62) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2992010 | 0.81 | GAA (0.64) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13296438 | 0.80 | TSHR (0.63) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4061712 | 0.80 | TSHR (0.68) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2570435 | 0.79 | LMNA (0.57) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5712121 | 0.76 | MEN1 (0.57) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3258566 | 0.76 | MAPT (0.54) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2997310 | 0.76 | GAA (0.62) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2566837 | 0.76 | ALDH1A1 (0.59) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13314764 | 0.76 | TSHR (0.61) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4028385-A1 | USP30 INHIBITORS AND USES THEREOF | Vincere Biosciences, Inc. (US) | 2022-07-20 | — | — | EP | disclosed |
| WO-2021050992-A1 | USP30 INHIBITORS AND USES THEREOF | VINCERE BIOSCIENCES, INC. (US) | 2021-03-18 | — | — | WO | disclosed |
| EP-2417122-A1 | INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT | PTC Therapeutics, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117932-A1 | INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |