Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | MC4R | P32245 | 12/20 | 0.52 |
| ▸ | WDR5 | P61964 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4816195 | 0.97 | KCNH2 (0.67) | KCNH2MC4RWDR5 | |
| SCHEMBL4823054 | 0.92 | KCNH2 (0.50) | KCNH2WDR5 | |
| SCHEMBL4071377 | 0.78 | KCNH2 (1.00) | KCNH2MC4R | |
| SCHEMBL7210824 | 0.78 | KCNH2 (0.66) | KCNH2MC4R | |
| SCHEMBL4825430 | 0.77 | KCNH2 (0.76) | KCNH2MC4R | |
| SCHEMBL6670018 | 0.77 | LMNA (0.54) | WDR5 | |
| SCHEMBL7210928 | 0.74 | KCNH2 (0.65) | KCNH2MC4R | |
| SCHEMBL4822543 | 0.73 | KCNH2 (0.82) | KCNH2MC4R | |
| SCHEMBL4822793 | 0.73 | MC4R (0.67) | KCNH2MC4R | |
| SCHEMBL4009351 | 0.73 | KCNH2 (0.56) | KCNH2MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644337-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Gene Logic, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005121100-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | GENE LOGIC INC. (US) | 2005-12-22 | — | — | WO | disclosed |