Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 10/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5793603 | 0.81 | KDM1A (0.42) | F2NAAA | |
| SCHEMBL5791866 | 0.81 | TAAR1 (0.43) | TAAR1XIAPCTSL | |
| SCHEMBL5794668 | 0.78 | XIAP (0.39) | TAAR1XIAPCTSLHDAC1HDAC2 | |
| SCHEMBL5794096 | 0.78 | XIAP (0.39) | TAAR1XIAPCTSLHDAC1HDAC2 | |
| SCHEMBL5793583 | 0.78 | XIAP (0.47) | TAAR1XIAPHDAC1HDAC2HDAC8 | |
| SCHEMBL4841143 | 0.77 | PSEN1 (0.47) | F2 | |
| SCHEMBL4840504 | 0.77 | PSEN1 (0.47) | F2 | |
| SCHEMBL4843123 | 0.76 | PSEN1 (0.49) | F2 | |
| Hydrochloric Acid SCHEMBL25342642 | 0.74 | XIAP (0.43) | XIAP | |
| Hydrochloric Acid SCHEMBL25342639 | 0.74 | XIAP (0.43) | XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |