Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 11/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794668 | 1.00 | XIAP (0.39) | XIAPTAAR1HDAC1HDAC2HDAC8 | |
| SCHEMBL5794093 | 0.82 | KDM1A (0.45) | — | |
| SCHEMBL5794664 | 0.82 | KDM1A (0.45) | — | |
| SCHEMBL4843190 | 0.78 | PSEN1 (0.44) | — | |
| SCHEMBL4839952 | 0.78 | PSEN1 (0.44) | — | |
| SCHEMBL5794458 | 0.78 | XIAP (0.39) | XIAPTAAR1 | |
| SCHEMBL5793607 | 0.78 | TAAR1 (0.40) | XIAPTAAR1HDAC1HDAC2HDAC8 | |
| SCHEMBL4842242 | 0.78 | PSEN1 (0.49) | — | |
| SCHEMBL4842158 | 0.78 | PSEN1 (0.49) | — | |
| SCHEMBL5794437 | 0.77 | XIAP (0.43) | XIAPTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |