Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.51 |
| ▸ | CTSL | P07711 | 5/20 | 0.36 |
| ▸ | CTSB | P07858 | 3/20 | 0.36 |
| ▸ | GPR4 | P46093 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270728 | 0.84 | CTSK (0.42) | CTSKCTSLCTSBCTSS | |
| SCHEMBL5791767 | 0.82 | CTSK (0.40) | CTSKCTSLCTSBGPR4CTSS | |
| SCHEMBL5794349 | 0.81 | CTSK (0.39) | CTSKCTSLCTSBGPR4CTSS | |
| SCHEMBL5794370 | 0.80 | CTSK (0.38) | CTSKCTSLCTSBGPR4CTSS | |
| SCHEMBL5792335 | 0.79 | CTSK (0.37) | CTSKCTSLCTSBCTSS | |
| Trifluoroacetic Acid SCHEMBL5792736 | 0.78 | CTSK (0.38) | CTSKCTSLCTSBCTSS | |
| SCHEMBL8270526 | 0.78 | CTSK (0.36) | CTSKCTSLCTSBCTSS | |
| SCHEMBL5791458 | 0.78 | KMT2A (0.41) | CTSKCTSLCTSBCTSS | |
| SCHEMBL8269410 | 0.76 | CTSK (0.39) | CTSKCTSLCTSBGPR4CTSS | |
| SCHEMBL2227354 | 0.75 | CTSK (0.53) | CTSKGPR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |