Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 5/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270728 | 0.94 | CTSK (0.42) | CTSKCTSSMEN1KMT2ACTSL | |
| Trifluoroacetic Acid SCHEMBL5791877 | 0.84 | CTSK (0.34) | CTSKCTSSCTSLCTSB | |
| Trifluoroacetic Acid SCHEMBL5791713 | 0.84 | CTSK (0.37) | CTSKCTSSHRH4HRH3CTSL | |
| Trifluoroacetic Acid SCHEMBL5794085 | 0.82 | CTSS (0.36) | CTSKCTSSHRH4HRH3CTSL | |
| Trifluoroacetic Acid SCHEMBL5791565 | 0.81 | CTSK (0.35) | CTSKCTSSHRH4HRH3MEN1 | |
| Trifluoroacetic Acid SCHEMBL5794657 | 0.81 | RECQL (0.35) | CTSKCTSSMEN1KMT2ACTSL | |
| Trifluoroacetic Acid SCHEMBL5792604 | 0.81 | CTSK (0.43) | CTSKCTSSHRH4HRH3MEN1 | |
| Trifluoroacetic Acid SCHEMBL5791991 | 0.80 | FPR2 (0.40) | MEN1KMT2A | |
| SCHEMBL5794349 | 0.80 | CTSK (0.39) | CTSKCTSSCTSLCTSBLMNA | |
| Trifluoroacetic Acid SCHEMBL5791505 | 0.80 | LMNA (0.40) | CTSKMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |