Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479981 | 0.87 | KCNN4 (0.43) | MAPK1CYP3A4KDM4EKMT2AMEN1 | |
| SCHEMBL10245188 | 0.80 | MAPK1 (0.53) | MAPK1CYP3A4KDM4EKMT2AMEN1 | |
| SCHEMBL8254401 | 0.80 | MAPK1 (0.53) | MAPK1CYP3A4KDM4EKMT2AMEN1 | |
| SCHEMBL569600 | 0.80 | KIF11 (0.44) | MAPK1CYP3A4KDM4ELMNA | |
| SCHEMBL14559281 | 0.80 | KIF11 (0.44) | MAPK1CYP3A4KDM4ELMNA | |
| SCHEMBL3302429 | 0.80 | KCNN4 (0.47) | KDM4EKMT2AMEN1MAPTTRPA1 | |
| SCHEMBL2490293 | 0.80 | KCNN4 (0.38) | MAPK1CYP3A4KDM4EKMT2AMEN1 | |
| SCHEMBL3302423 | 0.80 | KCNN4 (0.47) | KDM4EKMT2AMEN1MAPTTRPA1 | |
| SCHEMBL569601 | 0.80 | KIF11 (0.44) | MAPK1CYP3A4KDM4ELMNA | |
| SCHEMBL7745276 | 0.80 | MAPK1 (0.53) | MAPK1CYP3A4KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060223814-A1 | Nk-2 antagonist basic linear compounds and formulations containing them | MENARINI RICERCHE S.P.A. (IT) | 2006-10-05 | — | — | US | disclosed |
| EP-1620432-A1 | NK-2 ANTAGONIST BASIC LINEAR COMPOUNDS AND FORMULATIONS CONTAINING THEM | Menarini Ricerche S.p.A. (IT) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004094412-A1 | NK-2 ANTAGONIST BASIC LINEAR COMPOUNDS AND FORMULATIONS CONTAINING THEM | MENARINI RICERCHE S.P.A. (IT) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223814-A1 | Nk-2 antagonist basic linear compounds and formulations containing them | BDKRB2, KLK2, BDKRB1 | MAPK1 1428/4885CYP3A4 1308/4885KDM4E 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.