Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.45 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 3/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794093 | 1.00 | KDM1A (0.45) | KDM1AHTRA1F2SCN3AKDM4E | |
| SCHEMBL5794096 | 0.82 | XIAP (0.39) | — | |
| SCHEMBL5794668 | 0.82 | XIAP (0.39) | — | |
| SCHEMBL5794455 | 0.78 | KDM1A (0.48) | KDM1AHTRA1SCN3AMEN1KMT2A | |
| SCHEMBL5793603 | 0.78 | KDM1A (0.42) | KDM1AF2SCN3AKDM4EFAAH | |
| SCHEMBL5793469 | 0.77 | KDM1A (0.44) | KDM1AHTRA1F2SCN3AMEN1 | |
| SCHEMBL5794434 | 0.77 | KDM1A (0.44) | KDM1AHTRA1F2SCN3AMEN1 | |
| SCHEMBL4839952 | 0.72 | PSEN1 (0.44) | — | |
| SCHEMBL4843190 | 0.72 | PSEN1 (0.44) | — | |
| SCHEMBL5764210 | 0.72 | KDM1A (0.52) | KDM1AHTRA1F2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |