SCHEMBL5794795

SCHEMBL5794795

Cn1ccc2c3c(N)nc(N)nc3c(I)c(-c3ccc(O)cc3)c21

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DHFR P00374 2/20 0.40
PIK3CG P48736 3/20 0.36
LIMK1 P53667 1/20 0.33
HSD11B1 P28845 1/20 0.31
USP7 Q93009 4/20 0.31
RPS6KA3 P51812 1/20 0.30
HRH4 Q9H3N8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5798382 0.87 PIK3CG (0.41) DHFRPIK3CGLIMK1
SCHEMBL5796211 0.84 DHFR (0.35) DHFR
SCHEMBL5798453 0.77 MAP4K4 (0.40) LIMK1USP7
SCHEMBL5798083 0.77 DHFR (0.36) DHFRPIK3CGLIMK1HRH4
SCHEMBL5798079 0.77 CDK2 (0.39) DHFR
SCHEMBL5799326 0.75 FFAR1 (0.43) DHFR
SCHEMBL5798735 0.74 DHFR (0.36) DHFR
SCHEMBL5773193 0.74 DHFR (0.34) DHFR
SCHEMBL4688376 0.74 DHFR (0.50) DHFRUSP7
SCHEMBL5796107 0.73 DHFR (0.36) DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1628979-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-01 EP claimed
WO-2004101568-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-11-25 WO claimed
EP-1628979-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-01 EP disclosed
WO-2004101568-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-11-25 WO disclosed