Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 7/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605452 | 0.85 | JAK2 (0.46) | DRD4SIGMAR1DRD3TMEM97 | |
| SCHEMBL2567141 | 0.82 | NPC1 (0.58) | S1PR5NPC1RAB9AHRH3CHRM4 | |
| SCHEMBL606618 | 0.80 | OPRM1 (0.46) | DRD4SIGMAR1DRD3TMEM97LMNA | |
| SCHEMBL613535 | 0.78 | CARM1 (0.49) | DRD4SIGMAR1DRD3TMEM97 | |
| SCHEMBL606943 | 0.76 | SIGMAR1 (0.45) | DRD4SIGMAR1DRD3TMEM97 | |
| SCHEMBL603022 | 0.74 | KDM4E (0.46) | DRD4SIGMAR1DRD3TMEM97HRH3 | |
| SCHEMBL603681 | 0.74 | CARM1 (0.53) | DRD4SIGMAR1DRD3TMEM97HRH3 | |
| SCHEMBL5487632 | 0.73 | CARM1 (0.51) | DRD4SIGMAR1DRD3TMEM97NPC1 | |
| SCHEMBL605534 | 0.72 | CARM1 (0.49) | DRD4SIGMAR1DRD3TMEM97 | |
| SCHEMBL5475202 | 0.72 | CARM1 (0.53) | DRD4SIGMAR1DRD3TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651634-A1 | IMIDAZOL DERIVATIVES OF PIPERIDINE AS HISTAMINE ANTAGONISTS | AstraZeneca AB (SE) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014579-A1 | IMIDAZOL DERIVATIVES OF PIPERDINE AS HISTAMINE ANTAGONISTS | ASTRAZENECA AB (SE) | 2005-02-17 | — | — | WO | disclosed |