Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 3/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 3/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791378 | 0.78 | ALDH1A1 (1.00) | ALDH1A1MAPTKDM4EHSD17B10LMNA | |
| SCHEMBL17285533 | 0.76 | ALDH1A1 (0.61) | ALDH1A1MAPTPPARGNCOA2NCOA1 | |
| SCHEMBL25310305 | 0.73 | ALDH1A1 (0.76) | ALDH1A1KDM4EHSD17B10LMNASMN1; SMN2 | |
| SCHEMBL17285587 | 0.73 | ALDH1A1 (0.57) | ALDH1A1MAPTPPARGNCOA2NCOA1 | |
| SCHEMBL5307615 | 0.72 | MAPT (0.54) | ALDH1A1MAPTKDM4EHSD17B10PPARG | |
| SCHEMBL5269625 | 0.72 | POLB (0.54) | ALDH1A1MAPTKDM4ELMNAPPARG | |
| SCHEMBL5793071 | 0.71 | MAPT (0.56) | ALDH1A1MAPTKDM4EHSD17B10PPARG | |
| Potassium Ion SCHEMBL5793720 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4EHSD17B10LMNA | |
| SCHEMBL6320498 | 0.71 | ALDH1A1 (0.56) | ALDH1A1MAPTPPARGNCOA2NCOA1 | |
| Potassium Ion SCHEMBL5793717 | 0.70 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4EHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644353-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | Bayer HealthCare AG (DE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003118-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | WO | disclosed |