Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 6/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795738 | 0.86 | MAPK13 (0.46) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5798606 | 0.83 | MAPK13 (0.46) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5798480 | 0.80 | MAPK13 (0.40) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5799356 | 0.78 | MAPK13 (0.47) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5796380 | 0.77 | MAPK11 (0.39) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5809579 | 0.77 | MAPK11 (0.49) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5813023 | 0.77 | CYP2C9 (0.37) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5799224 | 0.77 | MAPK13 (0.37) | MAPK13MAPK11CYP2C9FGFR1FGFR2 | |
| SCHEMBL5795724 | 0.77 | MAPK13 (0.37) | MAPK13MAPK11CYP2C9MAPK12MAPK14 | |
| SCHEMBL5796356 | 0.76 | MAPK13 (0.40) | MAPK13MAPK11CYP2C9MAPK12MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |