Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.30 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794319 | 1.00 | KDM1A (0.45) | KDM1AXIAPOPRK1BRD4TSHR | |
| SCHEMBL5794323 | 0.82 | XIAP (0.46) | XIAPKMT2A | |
| SCHEMBL5795407 | 0.82 | XIAP (0.46) | XIAPKMT2A | |
| SCHEMBL5792552 | 0.79 | KDM1A (0.49) | KDM1AXIAPOPRK1BRD4KMT2A | |
| SCHEMBL5791214 | 0.79 | KDM1A (0.49) | KDM1AXIAPOPRK1BRD4KMT2A | |
| SCHEMBL5791597 | 0.79 | KDM1A (0.46) | KDM1A | |
| SCHEMBL5794394 | 0.77 | KDM1A (0.41) | KDM1AXIAPTSHR | |
| SCHEMBL5791515 | 0.74 | KDM1A (0.42) | KDM1AXIAPTSHRKMT2APOLB | |
| SCHEMBL5792639 | 0.73 | KDM1A (0.56) | KDM1ABRD4KMT2ASRD5A1 | |
| SCHEMBL5793469 | 0.72 | KDM1A (0.44) | KDM1AOPRK1KMT2AHSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |