Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.70 |
| ▸ | CNR2 | P34972 | 15/20 | 0.65 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | RORA | P35398 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 2/20 | 0.54 |
| ▸ | RORB | Q92753 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28304215 | 0.99 | PGR (0.68) | PGRCNR2PSEN1PSEN2APH1B | |
| SCHEMBL3011106 | 0.99 | PGR (0.68) | PGRCNR2PSEN1PSEN2APH1B | |
| SCHEMBL28305156 | 0.99 | PGR (0.68) | PGRCNR2PSEN1PSEN2APH1B | |
| SCHEMBL28304199 | 0.99 | PGR (0.68) | PGRCNR2PSEN1PSEN2APH1B | |
| SCHEMBL5514950 | 0.90 | PSEN1 (0.60) | PGRCNR2PSEN1PSEN2APH1B | |
| SCHEMBL5807330 | 0.90 | PGR (0.63) | PGRCNR2PSEN1PSEN2APH1B | |
| SCHEMBL4849333 | 0.83 | KDM4E (0.67) | PGR | |
| SCHEMBL554428 | 0.83 | CNR2 (0.63) | PGRCNR2PSEN1PSEN2APH1B | |
| SCHEMBL278343 | 0.83 | PGR (0.66) | PGRCNR2PSEN1PSEN2APH1B | |
| SCHEMBL14141738 | 0.82 | PGR (1.00) | PGRRORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006012310-A2 | CARBAZOLE DERIVATIVES FOR TREATING POLYCYSTIC KIDNEY DISEASE | GENZYME CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |