Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5824279 | 0.92 | KRAS (0.40) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5808341 | 0.84 | P2RX3 (0.49) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5808337 | 0.84 | P2RX3 (0.49) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5797415 | 0.84 | HDAC6 (0.70) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5811548 | 0.81 | HDAC6 (0.63) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5811555 | 0.81 | HDAC6 (0.63) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5796420 | 0.81 | HDAC6 (0.38) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5795528 | 0.79 | HDAC6 (0.39) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5795454 | 0.78 | KMT2A (0.40) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL5797757 | 0.78 | MEN1 (0.40) | HDAC6HDAC1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006025683-A1 | ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-03-09 | — | — | WO | disclosed |