Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4240548 | 0.87 | FGFR1 (0.43) | ADORA1IGF1RMAPK1MAPK14MAPK13 | |
| SCHEMBL5798902 | 0.86 | ADORA1 (0.55) | ADORA1IGF1RMAPK1MAPK14MAPK13 | |
| SCHEMBL7658127 | 0.85 | ADORA1 (0.53) | ADORA1IGF1RMAPK1MAPK14MAPK11 | |
| SCHEMBL7654930 | 0.84 | ADORA1 (0.60) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL8809138 | 0.82 | ADORA1 (0.64) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL5798621 | 0.79 | ADORA1 (0.55) | ADORA1IGF1RMAPK1MAPK14MAPK13 | |
| SCHEMBL7664915 | 0.79 | ADORA1 (0.53) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7039587 | 0.79 | ADORA1 (0.57) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL19829271 | 0.78 | ADORA1 (0.66) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL8810012 | 0.77 | ADORA1 (0.73) | ADORA1IGF1RMAPK1MAPK14MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |